Toxicological and Performance Aspects of Oxygenated Motor Vehicle Fuels by COMMITTEE ON TOXICOLOGICAL & PERFORMANCE ASPECTS OF OXYGENATED MOTOR VEHICLE FUELS

Author:COMMITTEE ON TOXICOLOGICAL & PERFORMANCE ASPECTS OF OXYGENATED MOTOR VEHICLE FUELS
Language: eng
Format: epub
Tags: Earth Sciences : Ecology and Ecosystems
Publisher: NATIONAL ACADEMY PRESS
Published: 1996-06-19T00:00:00+00:00

COMMITTEE CRITIQUE

One area not addressed in either the HEI or the OSTP report is the question of TBF toxicity. TBF is one of the major photooxidation byproducts of MTBE. If TBF levels are increased in the ambient air due to MTBE use, the available literature on TBF toxicity needs to be reviewed in the report. Based on that review and the extent of the exposures predicted, additional studies to characterize the acute and chronic toxicity of TBF may need to be added.

Based on the available data, the committee is skeptical about the need for additional studies based solely on the motor-activity studies conducted in rats. The committee notes that even at 800 ppm the effect, if any, is at an exposure of 100-1,000 times greater than predicted human exposures. It is also a reversible effect characteristic of this class of compounds and there is no indication of neuropathologic condition or persistent neurotoxicity following exposure to MTBE or other ethers.

Download

Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.